1 edition of Aplastic anemia found in the catalog.
Includes bibliographical references and index.
|Statement||James N. Parker and Philip M. Parker, editors|
|LC Classifications||RC641.7.A6 .A65 2004eb|
|The Physical Object|
|Format||[electronic resource] :|
|Pagination||1 online resource.|
Acquired aplastic anemia is a rare, serious blood disorder, due to failure of the bone marrow failure to produce blood cells. Bone marrow is the spongy substance found in the center of the bones of the body, in adults mainly the spine, pelvis, and large bones of the legs. The bone marrow contains hematopoietic stem cells. Stem cells can produce. Aplastic anemia definition is - anemia that is characterized by defective function of the blood-forming organs (such as the bone marrow) and is caused by toxic agents (such as chemicals or X-rays) or is idiopathic in origin.
Idiopathic aplastic anemia is a type of anemia in which your bone marrow stops making new blood cells. This can cause major health : Kristeen Moore. Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). Although the anemia is often normocytic, mild macrocytosis can also be observed in association with stress erythropoiesis and elevated fetal hemoglobin levels.
Read Article Now Book Mark Article Causes Aplastic anemia results from damage to the blood stem cells. Stem cells are immature cells in the bone marrow that give rise to all blood cell types (red blood cells, white blood cells, and platelets). Injury to the stem cells leads to a decrease in the number of these blood cell types. anemia. B. The majority of aplastic anemia cases are not linked to environmental exposures, but links to benzene and radiation exposure and some medications have been reported. C. Environmental factors associated with development of most cases of aplastic anemia include a wide array of infectious and chemical agents, drugs, and radiation. D.
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This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of aplastic anemia, a life-threatening hematological condition characterised by failure of cell regeneration mechanisms in bone marrow.5/5(1).
aplastic anaemia is the occurrence of the disease following exposure. There are no specific tests that can be used to identify with certainty the cause of the aplastic anaemia in any particular case. Despite all the difficulties in deciding whether a given File Size: KB.
Aplastic anemia occurs because of damage to stem cells inside bone marrow, which is the sponge-like tissue within your bones. Many diseases and conditions can damage the stem cells in bone marrow. As a result, the bone marrow makes fewer red blood cells, white blood cells, and platelets.
The most common cause of bone marrow damage is from your immune system. Severe aplastic anemia (SAA) is a life-threatening hematological disease characterized by suppression of the bone marrow. Diagnosis is made in the context of.
Diagnosis of Aplastic Anemia in Dogs It can take extensive testing to get a confirmed diagnosis of aplastic anemia in your dog due to the many and varied causes that can instigate this condition.
Your veterinarian will need to perform a full physical examination, as well as an extensive laboratory testing.
Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review. Boddu PC(1), Kadia TM(1). Author information: (1)a Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, by: Aplastic anemia Hypoplastic anemia; Bone marrow failure - aplastic anemia.
Aplastic anemia is a condition in which the bone marrow does not make enough blood cells. Bone marrow is the soft, tissue in the center of bones that is responsible for producing blood cells and platelets. This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia.
As well as providing a detailed overview of the pathophysiology of the disease, the international team of authors covers all. Inherited aplastic anemia is caused by gene defects, and is most common in children and young adults. If you have this type, there is a higher chance of.
Aplastic anemia is a disease in which the hematopoietic stem cell fails to adequately produce peripheral blood cells, causing pancytopenia. In some cases of acquired aplastic anemia and in inherited type of aplastic anemia, dyskeratosis congenita, telomere biology gene mutations and telomere shortening are etiologic.
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‘This book provide a comprehensive and up to date concepts on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. The book is an excellent and enjoyable to read. The amateur who is satisfied with certainty will drive more from it than the impartial professional seeking and challenge.
Aplastic anemia, an unusual hematologic disease, is the paradigm of the human bone marrow failure syndromes. Absence of hematopoietic cells has been recognized from the characteristic morphology for a century; an immune pathophysiology has been inferred from improvement in blood counts with immunosuppressive therapy in the majority of by: Despite the precision of its diagnostic criteria, aplastic anemia has always been a diagnosis of exclusion.
No single test allows us to reliably diagnose idiopathic aplastic anemia, but the field has advanced considerably in terms of awareness of and diagnosis of other disorders resulting in a similar or indistinguishable hematologic phenotype.
1–4 Consequently, the Cited by: Aplastic Anemia refers to a syndrome of bone marrow failure resulting in hypocellularity of the marrow and attendant pancytopenia, including anemia, thrombocytopenia, and neutropenia.A long list of etiologies, both inherited and acquired, can cause aplastic anemia although in the majority of patients the syndrome is idiopathic.
Bone marrow aplasia refers to those hematologic conditions that are caused by a marked reduction and/or defect in the pluripotent or committed stem cells, or the failure of the bone marrow microenvironment to support hematopoiesis.
The clinical outcome is anemia, leukopenia, and/or thrombocytopenia. The term “aplastic anemia” (AA) is a misnomer, because the. Aplastic anemia is a condition in which the body is unable to make blood cells that perform vital functions including infection control, oxygen transport, and tissue repair following injury.
While there are many causes for this disease, many patients never find the underlying issue. Anemia (also spelled anaemia) is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen. When anemia comes on slowly, the symptoms are often vague and may include feeling tired, weakness, shortness of breath, and a poor ability to exercise.
When the anemia comes on quickly, symptoms may Pronunciation: /əˈniːmiə/. The book is divided into four sections; the first three discuss community-acquired aplastic anemia and the last is devoted to Fanconi’s anemia. Part I does an outstanding job in addressing the pathophysiology of aplastic anemia and covers the areas of stem cell biology, cytokines, apoptosis, and autoimmunity as they relate to the : Robert A.
Brodsky. Diagnostic tests. The complete blood count in patients with aplastic anemia shows a “pancytopenia” meaning that there is a profound absence of the granulocytes among the white blood cells, a thrombocytopenia (platelet count far be per micro liter), missing red blood cells and low or missing reticulocytes.
Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets).
Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).Aplastic anemia is a disorder in which the cells of the bone marrow that develop into mature blood cells are damaged, leading to low numbers of red blood cells, white blood cells, and/or platelets.Research on aplastic anaemia has until recently been limited to clinical description, morphology and epidemiology.
New methods to culture haemopoietic cells, and advances in our knowledge of proliferation and differentiation in the haemopoietic cell .